To be eligible for the B.Tech degree program at Annapoorna Engineering College, Salem, candidates must have completed their 10+2 education with a minimum aggregate of 50% in Physics, Chemistry, and Mathematics. They must also have a valid score in entrance exams such as JEE Main or TNEA. Additionally, candidates from the reserved category must meet the specific eligibility criteria set by the college. It is also important for candidates to have a strong passion for engineering and a desire to excel in the field.